From Research Triangle Park:
NC-147 North / Take Duke St. Exit 12C / Turn Slight Right onto South Duke Street / South Duke Street becomes US-501 North / Travel 25.9 miles / Turn right onto Clayton Avenue (Total Distance 37.75 miles)

From Oxford:
US-158 West / Turn Right onto US-501 North / Travel 1.9 miles / Turn right onto Clayton Avenue (Total Distance 16.72 miles)

From Danville, Virginia:
US-58 East / Turn Right on VA-62-becomes NC-57 / Turn left onto
US-158 - Leasburg Rd - NC-49 - NC-57 / Turn left onto US-501 North - Madison Boulevard / Turn right onto Clayton Avenue (Total Distance 30.66 miles)